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(Korea University) (Korea University) (Korea University) (Korea University) (Korea University) (Korea University) (Korea University)
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한국생물공학회 한국생물공학회 학술대회 2015 한국생물공학회춘계학술발표대회 및 국제심포지엄
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    초록·키워드

    L-Cysteine is an important sulfur-containing amino acid in the food additives, cosmetic, pharmaceutical, and industries. The bio-based amino acid products have been recently preferred in the commercial or industrial market. Most amino acids are produced using commercial fermentation, whereas L-cysteine is mostly produced using acid hydrolysis of proteins. High-level L-cysteine production using metabolically engineered microorganism have not yet been achieved. The biosynthesis of L-cysteine need two precursors such as L-serine and sulfide (S2-). In this study, we have constructed the various single, double or triple mutant using Corynebacterium glutamicum ATCC 13032 strains for industrial production of amino acids. We examined the overexpression of transcriptional regulator (CysR) as a sulfur accumulation system activator (activation of genes encoding the sulfate or sulfonate uptake pathway for L-cysteine synthesis) for improving L-cys ... 전체 초록 보기

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      UCI(KEPA) : I410-ECN-0101-2016-470-001531265