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(New Mexico Veterans Affairs (VA) Health Care System) (New Mexico Veterans Affairs (VA) Health Care System) (New Mexico Veterans Affairs (VA) Health Care System) (New Mexico Veterans Affairs (VA) Health Care System)
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한국수산과학회 양식분과 한국수산과학회 양식분과 학술대회 2015년도 WORLD AQUACULTURE
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    초록·키워드

    Undariopsis peteseniana (U. Peteseniana), brown algae, is uniquely distributed in Jeju island of South Korea and generates abundant natural products, including antioxidant or anti-inflammatory properties. Cigarette smoke contains numerous oxidants and genotoxins that cause DNA damage and cytotoxicity both in vitro and in vivo. We hypothesize that apo-9’-fucoxanthinone (Apo9F) isolated from Undariopsis peteseniana protects against cigarette smoke-induced DNA damage and cytotoxicity. The Apo9F which is isolated from brown alga, Undariopsis peteseniana, suppresses DNA damage by augmenting DNA repair. We found that Apo9F protects against genotoxin (e.g. cigarette smoke [CS])-induced cytotoxicity in human bronchial epithelial cells (HBEC2). We also observed that Apo9F decreases CS-induced DNA damage and increases DNA repair proteins, including Werner’s syndrome protein and FANCD. Using ... 전체 초록 보기

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      UCI(KEPA) : I410-ECN-0101-2016-529-001668765