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(Sogang University) (Sogang University) (Sogang University) (Yonsei University College of Medicine) (Sogang University)
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한국미생물학회 한국미생물학회 학술대회논문집 2013년도 International Meeting of the Microbiological Society of Korea
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    초록·키워드

    VvhA produced by Vibrio vulnificus exhibits cytolytic activity to human cells including erythrocytes. Since hemolysis by VvhA may provide iron for bacterial growth and pathogenicity, we investigated the expression of VvhA to elucidate the regulatory roles of Fur, a major transcription factor controlling iron-homeostasis. Fur repressed the transcription of vvhBA operon via binding to the promoter region. However, hemolysin content and hemolytic activity were lowered in cell-free supernatant of fur mutant. This discrepancy between the levels of vvhA transcript and VvhA protein in fur mutant was caused by exoproteolytic activities of the elastase VvpE and another m ... 전체 초록 보기

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      UCI(KEPA) : I410-ECN-0101-2017-475-001058757