This paper tries to answer the question: “Is ‘Uberisation’ the end of economic regulation?” This paper start by reminding that specific features of the IT industries and of digital economics - huge positive economy of scale and two sided markets - lead to spontaneous monopolization. Another important patterns of the “digital revolution” 1.0 and 2.0 political economy is the combination of the applets revolution and the Great Recession, which has caused a lasting shift into a new economic paradigm that we call “Yard sale economy” and implied a profound distrust into public agencies and regulation. The Great Recession is thus bolstering the important and lasting changes in paradigm brought by technology. It gives full effect to economic regulation and regulators’ Uberisation by Internet 2.0 – more disruptive than the Internet 1.0 – through the new paradigm of “peer production economy” or “sharing economy”, sometime also called from a derogatory point of view “Uberisation”. As a case study, the reaction to Uber deployment in France demonstrates that Uberisation does not mean the end of public regulation even if it makes large public investment policies rather obsolete. Uberisation challenges traditional public regulation of professions as long as this regulation’s goal is to build trust thanks to command and control traditional regulation. Be that as it may, Uberisation lets some room for platform public regulation as has been drafted in the French recent “Digital Republic act”. In order to enforce at the international level these national legislations, the 2000 “LICRA v. Yahoo!” case hints at a combination of traditional court enforcement with international opinion digital campaign. All these elements call for “intelligent regulation”, a new regulatory paradigm based on pragmatic innovation-friendly regulation.