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논문 기본 정보

저자정보
(세명대학교) (세명대학교) (세명대학교)
저널정보
한의병리학회 동의생리병리학회지 동의생리병리학회지 제32권 제1호
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    초록·키워드

    In order to define the effect of Torilis Fructus(TF) extract which has been used for the treatment of erectile dysfunction, experiments were carried out by organ bath study, histochemical and immunohistochemical methods. First, in the organ bath study, when TF extract was administered to the maxillary contracted corpus cavernosum by PE (10-6 M), there was a significant relaxation effect on corpus cavernosum at concentration of 1, 3 ㎎/㎖. Compared with the absence of L-NNA pretreatmen, pretreatment of L-NNA was inhibited the relaxation effect of penile corpus cavernosum. In the immunohistochemical study, the eNOS positive reaction was significantly increased, and the PDE5 positive reaction was significantly decreased due to the administration of TF extract. Therefore, it show that the TF enhances the production of eNOS and NO, inhibits PDE5 which blocks the action of increased cGMP, relaxes the corpus cavernosum. So TF relaxes the corpus cavernosum and it can be used as a safer erectile dysfunction treatment.

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      UCI(KEPA) : I410-ECN-0101-2018-519-001809126