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논문 기본 정보

저자정보
(Wonkwang University) (Wonkwang University) (Wonkwang University) (Wonkwang University)
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한의병리학회 동의생리병리학회지 동의생리병리학회지 제33권 제1호
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    초록·키워드

    Interaction between epidermis and dermis plays an important role in wound healing and hair follicle formation. This study focused on investigating the potency of ethanol extract of Puerariae Radix (EPR) as cosmetic ingredient using human dermal fibroblasts (hDFn). Our results revealed that EPR suppressed collagenase activity dose-dependently. EPR inhibited activity of 5α-reductase I and II at the final concentration of 25 μg/ml in hDFn cells. Also, EPR promoted the proliferation and the ERK activation of cells. ERK phosphorylation by EPR was blocked by specific inhibitor of ERK, PD98059. EPR-induced cell proliferation was blocked by PD98059. This means that EPR could promote the proliferation of hDFn cells via the activation ERK. Collectively, these results suggest that EPR may be used as a new cosmetic ingredient.

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      UCI(KEPA) : I410-ECN-0101-2019-519-000513472