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논문 기본 정보

저자정보
(원광대학교) (뉴트라팜텍) (원광대학교)
저널정보
한의병리학회 동의생리병리학회지 동의생리병리학회지 제33권 제5호
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    초록·키워드

    In this study, we investigated the anti-obesity effects of various mixtures of Atractylodes macrocephala (AM) and Amomum villosum (AV) water extracts on high-fat diet (HFD) induced mouse model. We classified five groups as follows; control, HFD, HFD + AM extracts : AV extracts (100㎎/㎏) (1:1), HFD + AM extracts : AV extracts (100㎎/㎏) (2:1), HFD + AM extracts : AV extracts (100㎎/㎏) (3:1). Oral administration of various mixtures of AM and AV extracts for 6 weeks inhibited HFD-induced increases of body, liver and epididymal fat weights. Also, lipid profiles including LDL cholesterol were improved by various mixtures of AM and AV extracts treatment compared with HFD-fed group. Lipogenesis-related genes such as acetyl coA carboxylase (ACC) and fatty acid synthase (FAS) in liver changed in a favorable way for lipid biosynthesis by HFD compared to control, but various mixtures of AM and AV extracts-treated groups did not. Our results show that various mixtures of AM and AV extracts can prevent HFD-induced obesity in mice and suggests that the mechanisms are involved in expressions and modifications of lipogenesis-related genes such as ACC and FAS in liver.

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      UCI(KEPA) : I410-ECN-0101-2019-519-001283848