인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
피인용 0
초록·키워드
Migraine, also known as headache disorder is characterized by moderate to severe periodic attacks of acute headaches associated specifically with phonophobia, photophobia, and nausea with emotional, cognitive, autonomic, and motor disturbances. Neuroinflammation and oxidative stress are implicated in the pathogenesis of migraine in the central nervous system. Matrine is an alkaloid that is isolated from the Chinese herb Sophora flavescens. It possesses several pharmacological properties including anti-inflammatory, analgesic, and neuroprotective effects. The current study aimed to investigate the effects of matrine against migraine induced by the intraperitoneal administration of nitroglycerine (10 mg/kg) in mice. Matrine (50 mg/kg) significantly mitigated behavioral parameters such as mechanical allodynia, periorbital allodynia, thermal allodynia, and hyperalgesia. Nitroglycerine produced spectral changes in the brain tissues, which were reversed by treatment with matrine. Matrine also prevented histopathological and neurodegenerative changes in the cortex and trigeminal nucleus caudalis (TNC) regions. It remarkably improved the blood-brain barrier integrity along with a reduction in the levels of oxidative stress markers such as lipid peroxidase (LPO), nitric oxide (NO), myeloperoxidase (MPO), and eosinophil peroxidase (EPO) in the cortex regions of the brain. Furthermore, it also improved the antioxidant level such as glutathione (GSH), glutathione sulfotransferase (GST), catalase (CAT), and superoxide dismutase (SOD). Matrine also attenuated the NTG-induced neuroinflammation by inhibiting the tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) levels in the cortex region of the brain. HPLC analysis represented BBB permeability of matrine. Hence, the current findings suggest that matrine possesses neuroprotective properties in the nitroglycerine-induced migraine model.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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