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복합학
DBpia AI
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Citeasy
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지원사업
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커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
피인용 0
초록·키워드
Bletilla striata Reichenbach, a member of the Orchidaceae family has traditionally been used for wound healing, hemostasis, and reducing swelling due to its astringent properties. In this study, the 70% ethanol extract of B. striata tubers significantly reduced okadaic acid-induced tau hyperphosphorylation in HT22 cells, as determined by western blot analysis. Tau hyperphosphorylation is considered one of major contributors to Alzheimer" disease. The dichloromethane-partitioned fraction of the B. striata extract, which exhibited the strongest activity, was subjected to bioassay-guided isolation using various column chromatography techniques. This process led to the isolation and identification of three compounds: 3,7-dihydroxy-2,4-dimethoxyphenanthrene (1), coelonin (2) and 4-hydroxybenzyl-4,7-dimethoxy-9,10-dihydrophenanthrene-2-ol (3). All three compounds reduced tau hyperphosphorylation in a dose-dependent manner without exhibiting cytotoxicity. Notably, 4-hydroxybenzyl-4,7-dimethoxy-9,10-dihydrophenanthrene-2-ol (3) at 15 μg/mL significantly reduced tau hyperphosphorylation to 60% of the levels observed in the okadaic acid-only treated control group. These results suggest that B. striata extract and its active compounds may offer potential therapeutic benefits against Alzheimer’s disease by inhibiting tau hyperphosphorylation.
본문·목차
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