인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
In this study, we proposed the functional effect of the anti-inflammation effect of the Actinidia arguta ( A.a.) bee pollen and the molecular mechanism of its anti-inflammation. Two A.a. bee pollen samples commercially available in Korea were extracted in 70% ethanol, and finally dissolved in 35% ethanol to prepare a 100 mg/mL. The A.a. bee pollen extracts was treated with LPS, an inflammatory factor, to Raw264.7 macrophages. The A.a. bee pollen extracts reduced the NO production induced by LPS by approximately 60%, indicating that the A.a. bee pollen extracts had an anti-inflammatory effect. In addition, the intracellular molecular mechanism of the anti-inflammatory effect of the A.a. bee pollen was confirmed by Western blotting, and the expression of inflammation-related proteins such as iNOS, COX-2, NF-κB, and IL-1β induced by LPS was reduced by the A.a. bee pollen. In addition, the expression of intracellular antioxidant molecules such as SOD2 was also decreased. However, it did not affect the phosphorylation and expression of MAPKs that related intracellular division and apoptosis. The results of this study showed that the molecular mechanism of the inhibitory effect of the A.a. bee pollen extract on hyperimmunity caused by inflammatory factors, thereby providing a basis for the immune function of the Korean A.a. bee pollen and the increased utilization of the pollen.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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