인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
This study aimed to evaluate the effects of a mixture of Evodiae Fructus and three anti-inflammatory herbal medicines on esophageal damage in a rat model of acute reflux esophagitis (ARE). Rats were divided into six groups as follows: Normal, normal group; ARE, acute reflux esophagitis group; EF (water extract), Evodiae Fructus; CRE (EtOH extract), Cnidii Rhizoma + Evodiae Fructus; GRE (water extract), Ginseng Radix + Evodiae Fructus; CPE (water extract), Citri Unshius Pericarpium + Evodiae Fructus. Each group was administered a dose of 200 mg/kg. 60 min after administration, ARE was induced in all groups except the Normal group. Blood and esophageal tissue were collected 90 min after ARE induction. Subsequently, oxidative stress in the blood was measured, and the levels of inflammatory, antioxidant, and tight junction (TJ)-related proteins in esophageal tissue were analyzed by Western blot. The results indicated that the expression levels of these proteins were significantly lower in the CRE, GRE, and CPE administration groups compared to the ARE group. Additionally, the experiments revealed that the combinations of the three extracts increased the expression of claudin-4 and occludin, as well as antioxidant activity, with a particularly notable increase in tight junction (TJ) proteins in the CPE group.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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UCI(KEPA) : I410-151-25-02-092221512