인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
피인용 0
초록·키워드
Alzheimer's disease (AD) is the most common form of progressive neurodegenerative disease in the elderly and is characterized by memory and cognitive impairments. In patients with AD, memory and cognitive decline are associated with the formation of senile plaques, which are caused by the aggregation of β-amyloid (Aβ) peptides derived from amyloid precursor protein (APP). Additionally, AD patients exhibit reduced levels of acetylcholine, a neurotransmitter, due to the excessive production of acetylcholinesterase (AChE). In this study, we screened natural products for their inhibitory activities against Aβ secretion and AChE activity. The methanol extract of Dendrotrophe umbellata (Blume) Miq. (DUM) demonstrated inhibitory effects on both Aβ secretion and AChE activity. DUM reduced the secretion levels of Aβ42 and Aβ40 by 55% and 51%, respectively, at a concentration of 50 μg/mL. Furthermore, DUM exhibited a dose-dependent increase in sAPPα secretion and α-carboxy terminal fragment (CTF) levels at concentrations ranging from 10 μg/mL to 100 μg/mL. These results suggest that DUM inhibits β-secretase activity, thereby promoting the non-amyloidogenic pathway of APP metabolism at these concentrations. These findings reveal that DUM inhibits β-secretase, which competitively acts on APP, sharing the same substrate with α-secretase. Based on these results, we propose that DUM could serve as a natural resource to improve memory and cognition through β-secretase inhibition.
본문·목차
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UCI(KEPA) : I410-151-25-02-092171455
