인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
피인용 0
초록·키워드
Phthalates are used as plasticizers in plastics and other products, including household goods, and enter the human body mainly through oral, inhalation, and skin. Saponins in Korean red ginseng are known to have immune enhancement, central nervous system protection, anticancer, and anti-inflammatory properties. Therefore, the present study aimed to investigate the protective effects of Crude-saponin administration against DEHP-induced respiratory toxicity. A DEHP-induced respiratory toxicity model was performed using prepubertal 4-week-old SD rats, and the inflammatory response of blood and tissues obtained through autopsy was analyzed to determine the toxicity of DEHP and the protective effect of Crude-saponins against it. The results showed that MUC5AC and CCR3 were consistently increased in the DEHP-treated model, as well as the expression of key respiratory mucins. The inflammatory cytokines IL-13 and IL-5 increased, and TARC, which is responsible for Th2 migration, also tended to increase. However, the above phenomena gradually decreased in a concentration-dependent manner in the Crude-saponin-treated group. These results confirm that Crude-saponins are involved in gene protein expression inhibition and stress-induced mechanisms in respiratory injury. The expression of key respiratory mucins was consistently increased in the DEHP treatment model. As DEHP-induced impairment of NF-κB/MAPK signaling has been reported, further in vitro studies are needed to investigate the mechanisms involved in upstream signaling.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
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오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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