인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
피인용 0
초록·키워드
With infectious diseases and an aging population on the rise worldwide, there is a growing interest in boosting immunity to combat them. We aim to identify forest resources that can enhance immune function and scientifically prove their efficacy. We examined three different types of gami-saengmaeksan can increase the immune function in cyclophosphamide-induced immunosuppression mice. First, we injected cyclophosphamide (50 mg/kg) twice to induce immunosuppression. Then, three different types of gami-saengmaeksan (Prunus davidiana Carrière gami-saengmaeksan; PDS, Chaenomeles sinensis Koehne gami-saengmaeksan; CSS, Pyrus pyrifolia Nakai gami-saengmaeksan; PPS) 200 mg/kg/day were oral administered for 14 days. In order to confirm the immune-enhancing effect three different types of gami-saengmaeksan, we analyzed body weight chagne, the number of immune cells in blood, cytokines, and immunoglobulins levels in serum. Cyclophosphamide was decreased the mice body weight and the number of immune cells in blood. However, PDS and PPS have significantly increased the body weight, white blood cell, neutrophil, lymphocyte and monocyte count. Also, they were increased immune-related cytokines (IFN-γ, IL-2, IL-4, IL-6, IL-10, and TNF-α) and immunoglobulins (IgA, IgG, and IgM) levels in serum. But, CSS were slightly increased body weight, immune cells, cytokines, and immunoglobulins levels, non-significance was observed. The results suggest that the three types of gami-saengmaeksan can be used as ingredients in dietary supplements to immune enhancing.
본문·목차
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