인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
피인용 0
초록·키워드
Traditional Korean medicinal product consists of various traditional Korean medicines. Identification and assay are performed to confirm quality of traditional Korean medicinal product. Currently, assay of traditional Korean medicinal product requires a lot of analysis time due to an individual ingredient-specific pretreatment process. So it is necessary to improve it for reasonable quality control in pharmaceutical industry. In this study, we’ve focused on development of the simultaneous assay method with 12 marker compounds, which is applicable to every 87 traditional Korean medicinal products whose dosage form is ‘extract granules’, listed in the Korean Pharmacopoeia (KP) and the Korean Herbal Pharmacopoeia (KHP). The 12 characterizing compounds were amygdalin, geniposide, puerarin, paeoniflorin, hesperidin, 6,7-dimethylesculetin (scoparone), baicalin, berberine hydrochloride, cinnamic acid, paeonol, glycyrrhizic acid and schizandrin. We performed the validation and confirmed linearity, limit of detection, limit of quantitation, accuracy and precision. The R² value of linearity for characterizing compounds was ≥ 0.99, respectively. And the recovery rate was 80~120%, and the RSD was 15% or less. Also, it was confirmed that the contents of characterzing compound were similar comparing newly-developed test method to current test method. As a result, the developed simultaneous analysis methods have been reflected in Korean Herbal Pharmacopoeia and used for the quality control of traditional Korean medicinal products.
본문·목차
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UCI(KEPA) : I410-151-25-02-092841649
