인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
피인용 0
초록·키워드
Cardiovascular disease is a major health problem worldwide, and excessive platelet activation and aggregation are identified as the main causes of cardiovascular disease. Therefore, controlling platelet activation is a key strategy in the prevention and treatment of cardiovascular disease. Apigenin is a major flavonoid compound abundantly contained in the flowers of the chamomile plant, and previous studies have reported that it has anti-inflammatory, antiviral, and anticancer effects. However, the efficacy and mechanism of apigenin in inhibiting platelet activation and aggregation have not been clearly elucidated. This study confirmed the effect of apigenin on collagen-induced human platelets and clarified its mechanism of action. Apigenin inhibited the phosphorylation of phosphoproteins PI3K/Akt and MAPK during platelet activation, and also inhibited the phosphorylation of cPLA₂. In addition, apigenin reduced the production of TXA₂ and the release of intraplatelet granules such as ATP and serotonin. As a result, apigenin potently inhibited platelet aggregation induced by collagen, and ultimately affected the inhibition of thrombus formation. Through these results, this study shows that apigenin can be an effective antithrombotic substance that inhibits the activation and aggregation of human platelets by preventing granule release through the regulation of phosphorylated proteins.
본문·목차
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