인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
피인용 0
초록·키워드
Macrophage differentiation of U937 monocytes is induced by PMA stimulation, which is driven by the expression and phosphorylation of numerous intracellular proteins. We prepared honey, propolis, and a mixture of honey and propolis called Honeypolis, and confirmed the inhibition of macrophage differentiation by PMA. PMA at 10 ng/mL promoted U937 macrophage differentiation, accompanied by increased expression and phosphorylation of TLR4, CK2-α, PPAR-γ, NF-κB, and SOCS3. Furthermore, the U937 cells differentiated into macrophages and became adherent to the culture dish. However, when propolis and Honeypolis were co-treated with PMA, macrophage differentiation was inhibited and cell morphology remained unchanged, and adherent cells were not observed. In addition, propolis and honeypolis were affected the expression and phosphoryaltion of intracellular protein molecules, decreasing the expression of TLR4, CK2-α, SOCS3, and PPAR-γ and the phosphorylation of NF-κB and PPAR-γ. In addition, propolis and honeypolis regulated the major protein of MAPK such as p38 phosphorylation and SAPK/JNK phosphorylation and expression. Especially, honeypolis showed a higher effect on protein expression and phosphorylation than propolis, indicating that the combination of honey and propolis exhibited a synergistic functional effect. In conclusion, our results show that both propolis and honeypolis inhibit PMA-induced U937 macrophage differentiation. And our study suggests that propolis has the immunosuppressive effects, and our results provided in vitro data for immunosuppressive agents application.
본문·목차
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UCI(KEPA) : I410-151-26-02-094346320
