인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
This experiment was conducted to find anti-aging compounds using nematodes from natural products. After sep-arating the ikarisoside A from Epimedium koreanum Nakai (Berberidaceae), an anti-aging experiment was followed using a Caenorhabditis elegans model. The nematodes treated with ikarisoside A showed lifespan extension effect under general culture conditions. In addition, ikarisoside A increased the survival rate of C. elegans in stressful environments such as heat and osmotic conditions. To study the expression level of HSP-16.2, we used a transgenic strain including CL2070, and ikarisoside A-treated worms had a higher HSP-16.2::GFP intensity compared to untreated CL2070 worms. Nematodes fed the ikarisoside A showed reduced lipofuscin accumulation compared to control worms. Furthermore, there were no significant changes due to ikarisoside A in aging-related factors such as food intake, exercise, reproduction, and growth, indicating that ikarisoside A induces longevity activities without affecting these factors. These results indicate that ikarisoside A can affect longevity of C. elegans under both normal and stress conditions through the expression of stress-resistant proteins.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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UCI(KEPA) : I410-151-26-02-095629195