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논문 기본 정보

저자정보
(Woosuk University) (National Institute of Animal Science) (Woosuk University)
저널정보
한국생약학회 생약학회지(Korean Journal of Pharmacognosy) 생약학회지 제56권 제4호
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    초록·키워드

    This experiment was conducted to find anti-aging compounds using nematodes from natural products. After sep-arating the ikarisoside A from Epimedium koreanum Nakai (Berberidaceae), an anti-aging experiment was followed using a Caenorhabditis elegans model. The nematodes treated with ikarisoside A showed lifespan extension effect under general culture conditions. In addition, ikarisoside A increased the survival rate of C. elegans in stressful environments such as heat and osmotic conditions. To study the expression level of HSP-16.2, we used a transgenic strain including CL2070, and ikarisoside A-treated worms had a higher HSP-16.2::GFP intensity compared to untreated CL2070 worms. Nematodes fed the ikarisoside A showed reduced lipofuscin accumulation compared to control worms. Furthermore, there were no significant changes due to ikarisoside A in aging-related factors such as food intake, exercise, reproduction, and growth, indicating that ikarisoside A induces longevity activities without affecting these factors. These results indicate that ikarisoside A can affect longevity of C. elegans under both normal and stress conditions through the expression of stress-resistant proteins.

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      UCI(KEPA) : I410-151-26-02-095629195