메뉴 건너뛰기
소속 기관 / 학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
고객센터 ENG
주제분류

논문 기본 정보

저자정보
(한국생명공학연구원) (바이오메이신) (우석대학교) (우석대학교)
저널정보
한국생약학회 생약학회지(Korean Journal of Pharmacognosy) 생약학회지 제56권 제4호
오류 신고하기

피인용 0

검색

    초록·키워드

    Reactive oxygen species (ROS) induce cell death and are associated with the development of cancer, cardiovascular, and neurodegenerative diseases. Therefore, antioxidants that suppress ROS are considered essential. In this study, the polyphenol and flavonoid contents of the ethanol extract of Cornus officinalis and its solvent fractions were determined, and their radical scavenging activities were evaluated using DPPH, ABTS, and xanthine-derived superoxide assays. The ethyl acetate fraction exhibited the strongest scavenging activity. In Caenorhabditis elegans, this fraction dose-dependently enhanced the activities of antioxidant enzymes such as superoxide dismutase (SOD) increased resistance to oxidative stress, and prolonged lifespan. It also improved thermotolerance and significantly upregulated the expression of SOD-3::GFP in the transgenic strain CF1553. These findings suggest that the ethyl acetate fraction of C. officinalis exerts potent antioxidant effects and contributes to stress resistance and longevity in C. elegans.

    최근 본 자료 전체보기

      UCI(KEPA) : I410-151-26-02-095629766