인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
피인용 0
초록·키워드
The flowers of Inula britannica var. japonica (Asteraceae) has been listed in the Korean Herbal Pharmacopoeia as a medicinal herb used to alleviate cough, phlegm, and gastrointestinal discomfort. Traditionally, it has been prescribed for inflammatory disorders such as bronchitis, as well as for metabolic diseases including diabetes and hypertension. Recent pharmacological studies have validated its traditional uses and revealed novel bioactivities such as anti-inflammatory, antioxidant, anti-obesity, and neuroprotective effects, largely attributed to its sesquiterpene lactones and flavonoid constituents. To investigate the neuroprotective and anti-stress potential of Inulae Flos, the present study employed a corticosterone-induced PC12 cell model, which mimics stress-induced neuronal dysfunction. In this study, hot-water and ethanolic extracts of Inulae Flos were evaluated for their protective effects on ROS generation, inflammatory cytokines, apoptosis and neurotrophic signaling including BDNF, NGF, and CREB activation in corticosterone-induced PC12 cells. The extracts significantly restored cell viability and reduced ROS production and apoptotic cell death. Western blot analysis revealed that Inulae Flos extracts upregulated the phosphorylation of CREB and enhanced the expression of BDNF and NGF, while suppressing the phosphorylation of ERK and p38 MAPK involved in inflammatory signaling. Markedly, Inulae Flos extract increased BDNF expression to the level comparable to the positive controls, L-theanine and fluoxetine. These findings demonstrate that Inulae Flos exerts a potent neuroprotective effect against glucocorticoid-induced neuronal stress by modulating oxidative, inflammatory, and neurotrophic pathways. The results suggest that Inulae Flos extract has promising potential as a functional ingredient for stress alleviation and brain health improvement.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
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