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자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
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Citeasy
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초록·키워드
Background: Social isolation reportedly induces excessive aggression and impairs hippocampal neurogenesis. In this study, we investigated whether Geijigadaehwang-tang (GDT), a traditional herbal formulation containing Rhei Radix et Rhizoma and Cinnamomi Ramulus, could ameliorate such behavioral and neurogenic deficits.
Methods and Results: We assessed aggressive behaviors in socially isolated mice. Isolation markedly increased aggressive responses compared to sham controls. GDT treatment significantly reduced the number of attacks on days 3 and 7 and lowered both the attack duration and biting frequency. Immunohistochemical analysis of the dentate gyrus revealed that the isolation substantially reduced DCX-positive immature neuron numbers, whereas GDT administration partially restored these counts. Network pharmacology profiling has identified numerous GDT-associated compounds that interact with neuroendocrine and neurotransmission-related targets, including the dopaminergic, adrenergic, GABAergic, and CRH receptor pathways. Enrichment analysis high-lighted neuroactive ligand-receptor interaction, PI3K-Akt signaling, calcium signaling, apoptosis regulation, and steroid hormone biosynthesis as major functional clusters, supporting the role of GDT in neural plasticity and stress-related behavior.
Conclusions: GDT attenuated isolation-induced aggression and partially rescued impaired hippocampal neurogenesis. Integrated network analysis suggests that its multimodal actions might involve the modulation of neurotransmitter systems, neuroendocrine pathways, and pro-survival signaling cascades. GDT represents a promising multitarget therapeutic candidate for stress-related behavioral dysregulation and neurogenic impairment.
Methods and Results: We assessed aggressive behaviors in socially isolated mice. Isolation markedly increased aggressive responses compared to sham controls. GDT treatment significantly reduced the number of attacks on days 3 and 7 and lowered both the attack duration and biting frequency. Immunohistochemical analysis of the dentate gyrus revealed that the isolation substantially reduced DCX-positive immature neuron numbers, whereas GDT administration partially restored these counts. Network pharmacology profiling has identified numerous GDT-associated compounds that interact with neuroendocrine and neurotransmission-related targets, including the dopaminergic, adrenergic, GABAergic, and CRH receptor pathways. Enrichment analysis high-lighted neuroactive ligand-receptor interaction, PI3K-Akt signaling, calcium signaling, apoptosis regulation, and steroid hormone biosynthesis as major functional clusters, supporting the role of GDT in neural plasticity and stress-related behavior.
Conclusions: GDT attenuated isolation-induced aggression and partially rescued impaired hippocampal neurogenesis. Integrated network analysis suggests that its multimodal actions might involve the modulation of neurotransmitter systems, neuroendocrine pathways, and pro-survival signaling cascades. GDT represents a promising multitarget therapeutic candidate for stress-related behavioral dysregulation and neurogenic impairment.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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UCI(KEPA) : I410-151-26-02-096382628
