인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
피인용 0
초록·키워드
Oxidative stress contributes to neuronal damage and neurodegenerative disease as Alzheimer’s disease (AD). While glutamate, a key neurotransmitter in the central nervous system, is fundamental to neuronal viability and normal brain function, its excessive accumulation leads to oxidative stress. In this study, we investigated the effect of Cheongwisan (CWS), as Korean medicine consist in 5 nature herbs, on glutamate-induced injury in HT22 cells and explored the underlying mechanism involved. Our results show that CWS significantly reduced neuronal cell death and apoptotic marker. Also, CWS has antioxidant effect, reducing reactive oxygen species (ROS) level and increasing antioxidant molecules as heme oxygenase-1 (HO1), NAD(P)H: quinone oxidoreductase 1 (NQO1). Western blot analysis revealed that CWS upregulated brain-derived neurotrophic factor (BDNF) and promoted the extracellular signal-regulated kinase (ERK), and cAMP response element binding protein (CREB), which were downregulated by glutamate. Furthermore, CWS promoted the translocation of nuclear factor erythroid 2-related factor 2 (NRF2) into the nuclear. Thus, CWS may protect hippocampal cells against glutamate-induced oxidative stress by acti- vating the BDNF/ERK/CREB and ERK/NRF2 signaling pathways, suggesting its therapeutic potential for AD.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
최근 본 자료 전체보기
UCI(KEPA) : I410-151-26-02-096642334
