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(서울대학교) (서울대학교) (서울대학교) (경북대학교) (서울대학교)
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한국실험동물학회 한국실험동물학회 학술발표대회 논문집 2010년 한국실험동물학회 국제학술대회
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    초록·키워드

    Purpose : This study was undertaken to evaluate the inhibitory effect of decursin on retinal neovascularization in mouse model of oxygen-induced retinopathy. Materials and Methods : Anti-angiogenic activity of decursin was evaluated by vascular endothelial growth factor (VEGF)-induced proliferation, migration and in vitro tube formation assay of human retinal microvascular endothelial cells (HRMECs). Also, inhibition of VEGFR-2 phosphorylation by decursin was measured by Western blot analysis. After intravitreal injection of decursin in the mouse model of ROP, retinal neovascularization was examined by fluorescence angiography and vessel counting in cross sections. The toxicity of decursin was evaluated through MTT assay in HRMECs as well as histological examination and immunohistochemistry for glial fibrillary acidic protein in the retina. Results : Dec ... 전체 초록 보기

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      UCI(KEPA) : I410-ECN-0101-2012-510-003770750