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논문 기본 정보

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한국실험동물학회 Laboratory Animal Research Laboratory Animal Research Vol.24 No.1
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    초록·키워드

    Mast cells are so widely recognized as critical effecter cells for allergic disorders and other immunoglobulin (lg) E-associated acquired immune responses. In addition, Mast cells play an essential role in an allergic inflammation, including asthma, atopic dermatitis and allergic rhinitis. This study was designed to evaluate whether the mixture of the Houttuynia cordata and Ulmus davidiana var. japonica water extracts mixture (HUM) could modulate the production of pro-inflammatory cytokines. HUM inhibited compound 48/80-induced systemic reactions in mice. HUM decreased immunoglobulin Emediated local allergic reactions, passive cutaneous anaphylaxis. Furthermore, HUM attenuated the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-α, IL-6 and IL-8 secretion in HMC-1 cells stimulated by PMA plus A23187. In addition, HUM did not significantly affect the cell viability and had no toxicity on the HMC-1 cells. In the ratio of various HUM, HUM 7:3 showed significant inhibitory effects on allergic reaction in cell experiments as well as animal experiments. Based on these results, HUM can be used for treatment of an allergic inflammation response.

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      UCI(KEPA) : I410-ECN-0101-2009-510-014753473