메뉴 건너뛰기

추천
검색
질문

논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국실험동물학회 Laboratory Animal Research Laboratory Animal Research Vol.24 No.1
발행연도
수록면
1 - 7 (7page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
이 논문의 연구방법이 궁금하신가요?
🏆
연구결과
이 논문의 연구결과가 궁금하신가요?
AI에게 요청하기
추천
검색
질문

초록· 키워드

Mast cells are so widely recognized as critical effecter cells for allergic disorders and other immunoglobulin (lg) E-associated acquired immune responses. In addition, Mast cells play an essential role in an allergic inflammation, including asthma, atopic dermatitis and allergic rhinitis. This study was designed to evaluate whether the mixture of the Houttuynia cordata and Ulmus davidiana var. japonica water extracts mixture (HUM) could modulate the production of pro-inflammatory cytokines. HUM inhibited compound 48/80-induced systemic reactions in mice. HUM decreased immunoglobulin Emediated local allergic reactions, passive cutaneous anaphylaxis. Furthermore, HUM attenuated the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-α, IL-6 and IL-8 secretion in HMC-1 cells stimulated by PMA plus A23187. In addition, HUM did not significantly affect the cell viability and had no toxicity on the HMC-1 cells. In the ratio of various HUM, HUM 7:3 showed significant inhibitory effects on allergic reaction in cell experiments as well as animal experiments. Based on these results, HUM can be used for treatment of an allergic inflammation response.
상세정보 수정요청해당 페이지 내 제목·저자·목차·페이지
정보가 잘못된 경우 알려주세요!

목차

  1. 재료 및 방법
  2. 결과
  3. 고찰
  4. 참고문헌

참고문헌

참고문헌 신청

최근 본 자료

전체보기
UCI(KEPA) : I410-ECN-0101-2009-510-014753473