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논문 기본 정보

자료유형
학술저널
저자정보
(Dong-Eui University)
저널정보
대한의생명과학회 대한의생명과학회지 대한의생명과학회지 제20권 제2호
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56 - 61 (6page)

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초록· 키워드

This study attempted to confirm the antioxidative potential of luteolin against tert-butyl hydroperoxide (t-BHP) induced oxidative damage and to investigate its molecular mechanism related to glutathione (GSH)-dependent enzymes in HepG2 cells. Treatment with luteolin resulted in attenuation of t-BHP induced generation of reactive oxygen species (ROS) and oxidative stress-mediated cell death. In addition, accelerated expression of GSH-dependent antioxidative enzymes, glutathione peroxidase (GPx) and glutathione reductase (GR), and heme oxygenase (HO)-1, as well as strengthened GSH content was induced by treatment with luteolin, which was in accordance with increased nuclear translocation of nuclear factor-erythroid 2 p45-related factor 2 (Nrf2), a transcription factor for phase 2 enzymes, in a dose-dependent manner. These results suggest that the cytoprotective potential of luteolin against oxidative damage can be attributed to fortified GSH-mediated antioxidative pathway and HO-1 expression through regulation of Nrf2 in HepG2 cells.
#Luteolin #Oxidative stress #Glutathione #Heme oxygenase-1 #Nuclear factor-erythroid 2 p45-related factor 2
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목차

  1. INTRODUCTION
  2. MATERIALS AND METHODS
  3. RESULTS AND DISCUSSION
  4. REFERENCES

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UCI(KEPA) : I410-ECN-0101-2015-500-001663689