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초록· 키워드

Phellinus linteus is known as a drug, which has pharmacological activity for various tumors and inflammatory diseases in Oriental Medicine. In the present study, it was examined the effects of liquor of fermentation using mycelium of P. linteus (LFMP), on the alterations of inflammation-related proteins and liver function markers with human hepatocarcinoma cells and rats. HepG₂ cells were treated with ethanol and LFMP for 24 hours, the morphology and expression of inflammatory proteins were examined by microscopy, Western blotting, RT-PCR, and immunohistochemistry. In the morphological observation, HepG₂ cells were dose-dependently damaged in cells treated ethanol, however, LFMP had no effect on the morphology. Also, the expressions of cyclooxygenase (COX)-1, COX-2, which are major inflammatory enzymes, inducible nitr ... 전체 초록 보기
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UCI(KEPA) : I410-ECN-0101-2009-470-017107649