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저자정보
(한국원자력연구원) (전북대학교) (한국원자력연구원) (한국원자력연구원) (한국원자력연구원) (한국원자력연구원) (한국원자력연구원)
저널정보
한국식품과학회 Food Science and Biotechnology Food Science and Biotechnology vol 18. no 4
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    초록·키워드

    This study is to investigate the anti-inflammatory effects of the ethylacetate extract of Rehmannia glutinosa (RGEAE). The anti-inflammatory activities using nitric oxide (NO), cytokine, and chemokine production in lipopolysaccharide (LPS)-induced RAW 264.7 cells were checked. Results indicated that RGEAE suppressed the NO, interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1) production in a dose-dependent manner. Inhibition of NO formation was due to a decrease in inducible NOS (iNOS) expression. It was also found that the anti-inflammatory activities of RGEAE resulted from its inhibitory role on the nuclear factor (NF)-κB activation and reactive oxygen species (ROS) production. Therefore, it is suggested that RGEAE has potential as a therapeutic material to attenuate the inflammatory disease such as rheumatoid arthritis.

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      UCI(KEPA) : I410-ECN-0101-2013-573-000874729