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한국약용작물학회 한국약용작물학회지 한국약용작물학회지 제22권 제5호
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    초록·키워드

    Curcuma longa L. leaf was extracted by water at 60℃ for 12 hours after being treatment of Ultra HighPressure under 500 MPa for 5-15 minute. The high pressure extraction for 15 minute (HPE15) was measured the highestextraction yield of 25.48% (w/w), compared to those from conventional extraction methods. The HPE15 showed the lowestcytotoxicity as 11.97% in adding 1.0 ㎎/㎖ of concentration. Also, HPE15 was measured the highest inhibition of hyaluronidaseas 44.48% in adding 1.0 ㎎/㎖. In addition, The production of NO from macrophages was measured as 7.06 μM in adding1.0 ㎎/㎖ of HPE15, which was lower than the those from others processes. Finally, HPE15 significantly reduced up to649.44 pg/㎖ of ProstaglandinE2 production from UV-irradiation. These results suggest that the Curcuma longa Linne leafextract from high pressure process might enhance the skin immune activities possibly by high elution of active componentsthan other processes.

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      UCI(KEPA) : I410-ECN-0101-2019-480-000588044