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한국약용작물학회 한국약용작물학회지 한국약용작물학회지 제23권 제1호
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    초록·키워드

    This study was carried out to investigate the effects of the Cirsium japonicum var. ussuriense (C. japonicum)extract on serum level of hormones from induced osteoporosis by ovariectomized rats. Two month-old rats were ovariectomized(OVX), remained untreated for 8 weeks, and were subsequently administered C. japonicum (200 ㎎/㎏) every day for8 weeks. We examined the effects of treated C. japonicum on ovariectomy-related changes in Insulin-like Growth Factors(IGF), Insulin-like Growth Factor binding protein-3 (IGBF-3), Estrogen, Calcium, and Phosporus. After 8 weeks, the serumlevels of IGF-I, -II, and IGFBP-3 were higher presented as compared to the other two groups (P < 0.05), in the C. japonicumextract treatment on OVX rats. There were differences between OVX and C. japonicum extract treated OVX rats in serumlevels of Ca<sup>2+</sup>, but Ca<sup>2+</sup> levels for the normal group was higher than for the other two groups. The C. japonicum extractincreased both serum IGFs and IGFBP-3 levels on induced osteoporotic rat by ovariectomized. Thus, these results revealedthat the C. japonicum extract is a possible role for improvement of osteoporosis induced-ovariectomized rats and has a greatpotential as an alternative tool for the treatment of osteoporosis.

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      UCI(KEPA) : I410-ECN-0101-2019-480-000586479