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초록·키워드
Background: Galgeun-tang used in traditional Korean medicine, is a mixture of the medicinal plants Cinnamomi Ramulus, Ephedrae Herba and Puerariae Radix, and has been prescribed for the treatment of various ailments, including fever. Although the use of traditional medicinal herbs to treat diseases has recently increased, their safety and toxicity profiles incompletely elucidated. Thus, we evaluated Galgeun-tang’s toxicity in male and female Sprague-Dawley rats.
Methods and Results: Galgeun-tang (1,000, 2,000 and 4,000 ㎎/㎏) was orally administered to rats for 13 weeks, and then, they were maintained for 4 weeks without administration (recovery period). Their clinical signs, and hematological and urinary properties, were monitored. The results showed that Galgeun-tang administeration slightly increased serum creatinine, urea nitrogen and, aspartate aminotransferase levels. Additionally, 2,000 and 4,000 ㎎/㎏ Galgeun-tang significantly increased urinary bilirubn and protein levels of male and female rats, which were restored during the recovery period.
Conclusions: The no-observed-adverse-effect level of orally administered Galgeun-tang was 4,000 ㎎/㎏ in both female and male rats, and no target organs were identified. In addition, 400 ㎎/㎏ was found to be the no-observed-effect level for toxicity under the study conditions.
Methods and Results: Galgeun-tang (1,000, 2,000 and 4,000 ㎎/㎏) was orally administered to rats for 13 weeks, and then, they were maintained for 4 weeks without administration (recovery period). Their clinical signs, and hematological and urinary properties, were monitored. The results showed that Galgeun-tang administeration slightly increased serum creatinine, urea nitrogen and, aspartate aminotransferase levels. Additionally, 2,000 and 4,000 ㎎/㎏ Galgeun-tang significantly increased urinary bilirubn and protein levels of male and female rats, which were restored during the recovery period.
Conclusions: The no-observed-adverse-effect level of orally administered Galgeun-tang was 4,000 ㎎/㎏ in both female and male rats, and no target organs were identified. In addition, 400 ㎎/㎏ was found to be the no-observed-effect level for toxicity under the study conditions.
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UCI(KEPA) : I410-ECN-0101-2019-480-000930993
