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논문 기본 정보

저자정보
(중앙대학교) (중앙대학교) (중앙대학교)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.35 No.1
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    초록·키워드

    Korean red ginseng (RG), which is a ginseng treated by heating and steaming, has biological activity similar to Panax ginseng. The effect of ginseng on influenza infection has not been studied although it is known to have a broad range of biological activities. The aim of the study is to investigate the effect of RG extract on infl uenza A (H1N1) virus infection. We investigated the inhibitory effect of RG extract on plaque formation by infl uenza A virus in a cell-based plaque assay, and the effect of orally administered RG on infl uenza A virus infection in mice. RG extract, which was applied at a non-cytotoxic concentration, inhibited plaque formation by infl uenza A virus in the cell-based plaque assay. The orally administered RG extract ameliorated body weight loss and signifi cantly increased survival in mice infected with infl uenza A virus. Our results suggest that RG extract has components that reduce the severity of infection by infl uenza A virus and could potentially be used as a complement to treatment of infl uenza A virus infections.

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      UCI(KEPA) : I410-ECN-0101-2012-524-004215885