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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Hemoglobin is oxygen carrier protein within erythrocyte in blood. Apoprotein of this, globin, is synthesized in the cytosol but it's cofactor, heme, is synthesized in the mitochondria. It has not been known very well how globin receives the heme from mitochondria and folds to hemoglobin. In this folding process, the initial structure of globin seems to be very important. A small volume of globin at acid pH was added rapidly into the bulk of an e99 phosphatidylcholine 60% liposome, containing hemins, at neutral pH according to the Rapid Dilution method. It was observed that an acid-induced unfolding structure of globin is initially needed to receive hemins from the lipid bilayer of liposomes. Also, this conclusion was confirmed with the absorption spectrum of the refolded globin separated by centrifugation.
목차
영어 초록
Hemin 함유 리포좀과 Acid-unfolded Globin의 상호작용
Hemin을 획득한 Refolded Globin의 UV-visible Absorbance Spectrum
결론 : Acid-unfolded Globin의 Refolding
REFERENCES
참고문헌 (26)
참고문헌 신청
[학술지(정기간행물)] - Bogdanov M, / 1998 / phosphatidylethanolamine is required at a late step of the conformational maturation of the polytopic membrane pro- tein lactose permease 17 : 5255 ~ 5264
[학술지(정기간행물)] - Bogdanov M / 1999 / vLipid-assisted protein folding 274 : 36827 ~ 36830
[학술지(정기간행물)] - Sun J / 1996 / A phospholipid acts as a chaperone in assembly of a membrane transport protein bogda (v m) : 11615 ~ 11618
[학술지(정기간행물)] - Bunn HF / 1987 / Subunit assembly of hemoglobin an important deter- minant of hematologic phenotype : 1 ~ 6
[학술지(정기간행물)] - Cannon JB / 1984 / Kinetics of the interaction of hemin liposomes with heme binding proteins : 3715 ~ 3721
[학술지(정기간행물)] - Bogdanov M / 1999 / vLipid-assisted protein folding 274 : 36827 ~ 36830
[학술지(정기간행물)] - Sun J / 1996 / A phospholipid acts as a chaperone in assembly of a membrane transport protein bogda (v m) : 11615 ~ 11618
[학술지(정기간행물)] - Bunn HF / 1987 / Subunit assembly of hemoglobin an important deter- minant of hematologic phenotype : 1 ~ 6
[학술지(정기간행물)] - Cannon JB / 1984 / Kinetics of the interaction of hemin liposomes with heme binding proteins : 3715 ~ 3721
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UCI(KEPA) : I410-ECN-0101-2009-510-017354185