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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 310 - 320 (11page)
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초록· 키워드
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Ginseng has been widely used for traditional medicine in eastern Asia and is known to have inhibitory effects on cardiovascular disease (CVD) such as thrombosis, atherosclerosis, and myocardial infarction. Because, platelet is a crucial mediator of CVD, many studies are focusing on inhibitory mechanism of platelet functions. Among platelet activating molecules, thromboxane A₂ (TXA₂) and P-selectin play a central role in CVD. TXA₂ leads to intracellular signaling cascades and P-selectin plays an important role in platelet-neutrophil and platelet-monocyte interactions leading to the inflammatory response. In this study, we investigated the inhibitory mechanisms of total saponin fraction from Korean red ginseng (KRG-TS) on TXA₂ production and P-selectin expression. Thrombin-elevated TXA₂ production and arachidonic acid release were decreased by KRG-TS dose (25 to 150 μg/mL)-dependently via down regulation of microsomal cyclooxygenase-1 (COX-1), TXA₂ synthase (TXAS) activity and dephosphorylation of cytosolic phospholipase A₂ (cPLA₂). In addition, KRG-TS suppressed thrombin-activated P-selectin expression, an indicator of granule release via dephosphorylation of mitogen-activated protein kinases (MAPK). Taken together, we revealed that KRG-TS is a beneficial novel compound inhibiting TXA₂ production and P-selectin expression, which may prevent platelet aggregation-mediated thrombotic disease.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (47)
참고문헌 신청
Adam F, Kauskot A, Nurden P, Sulpice E, Hoylaerts MF, Davis RJ, Bryckaert M. Platelet JNK1 is involved in secretion and thrombus formation. Blood. 2010. 115: 4083-4092.
Berridge MJ, Irvine RF. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature. 1984. 312: 315-321.
Borsch-Haubold AG, Pasquet S, Watson SP. Direct inhibition of cyclooxygenase-1 and-2 by the kinase inhibitors SB 203580 and PD 98059 SB 203580 also inhibits thromboxane synthase. Journal of Biological Chemistry. 1998. 273: 28766-28772.
Broos K, Feys HB, De Meyer SF, Vanhoorelbeke K, Deckmyn H. Platelets at work in primary hemostasis. Blood Reviews. 2011. 25: 155-167.
Bugaud F, Nadal-Wollbold F, Levy-Toledano S, Rosa JP, Bryckaert M. Regulation of c-jun-NH2 terminal kinase and extracellularsignal regulated kinase in human platelets. Blood. 1990. 94: 3800-3805.
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UCI(KEPA) : I410-ECN-0101-2018-510-001723191