인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2004.11
- 수록면
- 148 - 149 (2page)
이용수
초록· 키워드
The number of diabetic patients is increasing especially in Asia according to change of life habits (1). In mild case of diabetes, many patients are left without medical treatments and the long period of none treatment causes serious complications that impair the quality of life of the patients (2). Diabetes is a chronic disease that is characterized by hyperglycemia caused by insufficiency of the insulin action (3). So, we considered that edible ingredients which can complement insulin action are useful to prevent and cure diabetes and complications associated with the disease.
We tried to find the insulin mimic compounds from edible plants. We investigated the two insulin mimic activities of edible plant materials; (a) adipocyte differentiation activity and (b) enhancement activity of glucose uptake, using pre-adipocyte cell line 3T3-L1 (4,5). As a result, we found that ethanol extract of Angelica keiskei, a dropwort indigenous to Japan and called “Ashitaba”, has both activities (6). We tried to isolate active compounds from the extract, and we found that two major chalcons peculiar to Angelica keiskei, xanthoangelol (XA) and 4-hydroxyderricin (4HD) have both activities (a) and (b). Regarding adipocyte differentiation, XA and 4HD have the similar level of activities. On the other hand, regarding enhancement of glucose uptake, the activity of 4HD is several times as high as that of XA. Furthermore, the combination of XA and 4HD could complement insulin action (induction of adipocyte differentia ... 전체 초록 보기
상세정보 수정요청해당 페이지 내 제목·저자·목차·페이지We tried to find the insulin mimic compounds from edible plants. We investigated the two insulin mimic activities of edible plant materials; (a) adipocyte differentiation activity and (b) enhancement activity of glucose uptake, using pre-adipocyte cell line 3T3-L1 (4,5). As a result, we found that ethanol extract of Angelica keiskei, a dropwort indigenous to Japan and called “Ashitaba”, has both activities (6). We tried to isolate active compounds from the extract, and we found that two major chalcons peculiar to Angelica keiskei, xanthoangelol (XA) and 4-hydroxyderricin (4HD) have both activities (a) and (b). Regarding adipocyte differentiation, XA and 4HD have the similar level of activities. On the other hand, regarding enhancement of glucose uptake, the activity of 4HD is several times as high as that of XA. Furthermore, the combination of XA and 4HD could complement insulin action (induction of adipocyte differentia ... 전체 초록 보기
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목차
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참고문헌
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UCI(KEPA) : I410-ECN-0101-2009-511-018071782
