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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.3
- 수록면
- 37 - 43 (7page)
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초록· 키워드
We performed in vitro and in vivo studies to know whether the inhibitory effects of ginsenosides on 5-HT₃_A receptor channel acctivity are coupled to anti-nausea and anti-vomiting action. In vitro study, we investigated the effect of compound K (CK) and M4, which are ginsenoside metabolites, on human 5-HT₃_A receptor channel activity expressed in Xenopus oocytes using two-electrode voltage clamp technique. Treatment of CK or M4 themselves had no effect in both oocytes injected with H₂O and 5-HT₃_A receptor cRNA. In oocytes injected with 5-HT₃_A receptor cRNA, M4 treatment inhibited more potently 5-HT-induced inward peak current (I_5-HT) than CK with dose-dependent and reversible manner. The half-inhibitory concentrations (IC_50) of CK and M4 were 36.9±10.1 and 7.3±2.2㎛, respectively. The inhibition of l_5HT by M4 was non-competitive and voltage-independent. These results indicate that M4 might regulate 5-HT₃_A receptors. In vivo experiments, injection of cisplatin (7.5 ㎎/㎏, i.v.) induced both nausea and vomiting with 1 h latency. These episodes reached to peak after 2 h and persisted for 4 h. Pre-treatment of GTS (500㎎/㎏, p.o.) significantly reduced cisplatin-induced nausea and vomiting by 51±8.4 and 48.8±6.4% during 4 h compared to GTS-untreated group, respectively. These results show the possibility that in vitro inhibition of 5-HT₃_A receptor channel activity by ginsenosides might be coupled to in vivo anti-emetic activity.
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목차
- Abstract
- INTRODUCTION
- MATERIALS AND METHODS
- RESULTS AND DISCUSSION
- ACKNOWLEDGMENT
- REFERENCES
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참고문헌 신청최근 본 자료
UCI(KEPA) : I410-ECN-0101-2009-524-014547126
