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    Colon cancer is one of the most common malignancies in humans, and the search for effective chemopreventive agents is an important and urgent task. Expression levels of inflammation-related enzymes, cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) are elevated in colon cancers, and their products, prostaglandins and nitric oxide, are suggested to be involved in colon carcinogenesis. Thus, inhibition of COX and NOS activity is thought to be an appropriate approach for chemoprevention. Clear suppressive effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on colon cancer development have been reported and considered attributable to inhibition of COX, both constitutive COX-1 and inducible COX-2 forms, being involve ... 전체 초록 보기

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      UCI(KEPA) : I410-ECN-0101-2009-476-017705114