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논문 기본 정보
- 저자정보
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초록·키워드
The effects of IH901, a ginseng intestinal metabolite, on the antitumor activity and cardiotoxic adverse effect of doxorubicin were investigated in sarcoma-180 ascitic tumor-bearing mice. To evaluate the enhancing effect on the antitumor activity of doxorubicin, IH901 (50 ㎎/㎏) was orally administered for 28 days, in combination with intraperitoneal injection of doxorubicin (3 ㎎/㎏) on days 5, 12, 19 and 24, to mice intraperitoneally inoculated with 1 × 10? sarcoma-180 cells. The body weights of tumor-bearing mice dramatically increased from 10 days following tumor inoculation, leading to a mean survival time of 17.3 days. In contrast, such an increase in body weights induced by the ascitic tumor growth was markedly attenuated by doxorubicin (3 ㎎/㎏) administration, resulting in a long lifespan of 34.9 days. Interestingly, the body weight gain was further suppressed by the combination of IH901 (50 ㎎/㎏), leading to a normal feature. In addition, the mean survival time was extended by 129.3%, reaching 39.7 days, although IH901 was inactive alone. Separately, for the evaluation of protective effect on the cardiotoxicity of doxorubicin, IH901 (50 ㎎/㎏) was orally administered for 14 days, in combination with intraperitoneal injection of doxorubicin (5 ㎎/㎏) on days 5 and 9 to tumor-bearing mice. Although the heart weight of tumor-inoculated mice decreased to about 75% of normal, such an atrophy was remarkably recovered by coadministration of IH901. Furthermore, IH901 substantially reversed the dramatic decrease in mRNA of myocytic phospholipid hydroperoxide glutathione peroxidase, an antioxidant enzyme, as well as histopathological changes such as cytoplasmic vacuolization, mitochondrial swelling, and loss of myofibrils and intercalated disc induced by doxorubicin. Taken together, it is suggested that IH901 could be a potential adjunct for the potentiation of antitumor activity and reduction of cardiotoxicity of chemotherapeutic agents including doxorubicin.
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UCI(KEPA) : I410-ECN-0101-2009-510-016362156
