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    초록·키워드

    The selenium (Se) is now recognized as an essential component of various selenoenzymes. To study whether Se treatment affects the endoplasmic reticulum ER stress signaling pathway in the non-obese diabetic (NOD) mice, the indicator protein on the ER stress pathway was examined in the liver of the NOD mice by the western blot analysis. It was observed that Se acted as the insulin-like effects on glucose level in the Se-treated diabetes-susceptible (DS)-NOD mice. Nevertheless, Se treatment activated ER stress signal through the phosphorylation of JNK and eIF2 protein. In conclusion, these results suggest that Se component play an important role in the down-regulation of glucose level and the activation of some intermediate signaling proteins associated with ER stress signal pathway in the NOD mice.

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      UCI(KEPA) : I410-ECN-0101-2009-510-016362898