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자연과학
공학
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예술체육학
복합학
DBpia AI
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AI 아이디어
AI 리더
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Citeasy
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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
피인용 0
초록·키워드
The effects of GEY+RES, a preparation of combined glutathione-enriched yeast (GEY) and rice embryo/soybean (RES) extracts (20:1), on carbon tetrachloride (CCl₄)-induced hepatic injury were investigated in male Sprague-Dawley rats. The rats were orally administered with GEY+RES at low (GEY+RES=50+2.5 ㎎/㎏), medium (100+5 ㎎/㎏) or high (200+10 mg/kg) doses for 2 weeks, followed by intraperitoneal challenge with CCl₄ (1 mL/㎏) 30 min after the final treatment. Twenty four hours later, initial biliary excretion and time-course of blood concentration of intravenously-injected bromosulphalein were examined. In addition, blood parameters of hepatic injury in accordance with histopathological findings were analyzed. The biliary excretion time and clearance of bromosulphalein were greatly delayed by CCl₄ injection, which were recovered by GEY+RES in a dose-dependent manner, resulting in decreases to a half level by medium and high doses. CCl₄ drastically increased the blood markers of hepatotoxicity, and caused centrilobular congestion, hepatocytic degeneration, lipid droplets and inflammatory cell infiltration, leading to disintegration of hepatic cords. The increased biochemical parameters and hepatic lesions induced by CCl₄ were significantly attenuated by GEY+RES treatment. The results suggest that GEY+RES might prevent liver dysfunction induced by CCl₄, and that GEY+RES could be a potential candidate for the prevention of hepatic disorders.
본문·목차
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최근 본 자료 전체보기
UCI(KEPA) : I410-ECN-0101-2009-510-019510649
