인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
피인용 0
초록·키워드
Perfluorooctanoic acid (PFOA) is a widely used industrial chemical that induces reproductive toxicities. To gain a better understanding of the mechanism underlying the PFOA-induced spermatogenesis impairment, we investigated the effects of PFOA on spermatogenesis and germ cell apoptosis. Ten-week-old Sprague- Dawley rats were treated with PFOA 10 ㎎/㎏/day for 1 day or 5 ㎎/㎏/day for 3 days orally. Rats were euthanized in 12 hrs and 1, 2, 3 and 7 days after treatment. The effects of PFOA on the testes were examined by determining apoptosis and the possible role for Fas and Fas ligand (Fas-L) in atrophy of the testes by histopathology, TUNEL assays and immunoblot. PFOA administration did not lead to significant changes in body and testicular weights. All doses of PFOA showed similar pathological changes in the testes. Degeneration and apoptosis of germ cells was evident in 12 hr of PFOA treatment and progressively increased in a time-dependent manner until 2 days and then slightly decreased at 3 and 7 days after PFOA treatment. Fas and Fas-L protein levels were increased. Collectively, these data suggest that impaired spermatogenesis after PFOA treatment is associated with an increase in germ cell apoptosis and Fas and Fas-L play a significant role in the initiation and/or progression of PFOA-induced testicular damage.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
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최근 본 자료 전체보기
UCI(KEPA) : I410-ECN-0101-2010-510-001694200
