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자료유형
학술저널
저자정보
(가야대학교) (서울대학교) (서울대학교) (서울대학교) (서울대학교) (서울대학교) (서울대학교)
저널정보
한국영양학회 Nutritional Sciences Nutritional Sciences Vol.9 No.4
발행연도
수록면
240 - 247 (8page)

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초록· 키워드

In this study we investigated the neuroprotective, antioxidative, and hypocholestrolemic effects of dietary soy protein and soy isoflavone in a rat focal brain ischemia model. Weaning Sprague-Dawley rats were fed a 20% casein-based diet(CA), 20% soy protein-based diet(SP), or 0.2% soy isoflavones-supplemented diet(ISO) for 6 weeks. The cortical infarction volume of the ISO group was significantly lower than that of the SP group. The thiobarbituric acid reactive substances (TBARS) were considerably lower in the ISO group than the CA group. Glutathione peroxidase activities of the SP group were notably higher than those of the CA group. Acetylcholinesterase(AchE) activities of the SP group were significantly decreased compared to the CA group. LDL cholesterol levels and LDL/HDL ratios of the ISO group were lower than those of the CA and SP groups. Our results collectively suggest that soy isoflavones may contribute to neuroprotection by reducing the TBARS and serum LDL/HDL ratio, whereas soy protein may be associated with the regulation of cognitive functions by modulating AchE activity.
#Acetylcholinesterase #Infarction volume #LDL-cholesterol #Soy isoflavones #Soy protein
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목차

  1. INTRODUCTION
  2. MATERIALS AND METHODS
  3. RESULTS
  4. DISCUSSION
  5. Literature Cited

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UCI(KEPA) : I410-ECN-0101-2012-594-004194265