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초록·키워드
??The current study examined the effect of quercetin supplements on the lipid-lowering and antioxidant metabolism in ethanol-fed rats, The control group(E<sub>8</sub>) received ethanol only diet for 8 wks, whereas the other group(E<sub>8</sub>Q<sub>4</sub>) received a diet including quercetin supplementation(0.05%, wt/wt) for 4 wks while on the ethanol diet for 8wks. The hepatic alcohol dehydrogenase activity was significantly higher in the E<sub>8</sub>Q<sub>4</sub> group than in the E<sub>8</sub> group. Supplementation with quercetin significantly elevated the HDL- cholesterol concentration, the HDL-C/total-C ratio, and lowered the atherogenic index(AI) compared to the E<sub>8</sub> group. The hepatic triglyceride and cholesterol contents were significantly lowered by the quercetin supplement compared to those of the control group. The hepatic HMG-CoA reductase and ACAT activities of the E<sub>8</sub>Q<sub>4</sub>group were significantly lower than those of the E<sub>8</sub> group. The overall potential for antioxidant defense was significantly enhanced by the quercetin supplement, as indicated by a decrease in plasma and hepatic TBARS levels. The hepatic GSH-Px and G6PD activities were significantly higher in theE<sub>8</sub>Q<sub>4</sub> group compared to the E<sub>8</sub> group. The current results suggest that dietary quercetin leads to the inhibition of HMG-CoA reductase and ACAT, which in turn lowers cholesterol levels and normalizes antioxidant enzyme activities.
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최근 본 자료 전체보기
UCI(KEPA) : I410-ECN-0101-2012-594-004194285
