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논문 기본 정보

자료유형
학술저널
저자정보
(Chungbuk National University) (Chungbuk National University) (Chungbuk National University) (Chungbuk National University)
저널정보
충북대학교 동물의학연구소 Journal of Biomedical Research Journal of Biomedical Research Vol.12 No.2
발행연도
수록면
70 - 78 (9page)

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초록· 키워드

Peripheral nerve injuries are very common in clinics which often result in severe functional deficits. The aim of this study was to evaluate the effect of treadmill running and electro-acupuncture on the nerve regeneration and the functional recovery of muscle activity following sciatic nerve crushed injury in rat model. Comparative study was performed over 30 days on 60 adult male Sprague-Dawley rats grouped into sham control (C), electro-acupuncture (EA), treadmill (T) and treadmill plus electro-acupuncture (TEA). The left sciatic nerve was crushed for 30 sec by a hemostatic forceps and functional activity was evaluated with sciatic functional tests, nerve conduct velocity, muscle weight and histology at 10, 20, and 30 days after injury. The muscle weight was significantly (P<0.05) increased between days 10 and 30 in TEA group. In histology, the degree of damage was scored as C > TEA > T > EA, although the necrosis and fibrosis of muscle appeared only in TEA group. The EA and TEA groups showed fast recoveries with better myelinated axons at day 10. These results suggest that the application of TEA method with balanced exercise is a useful treatment option for peripheral nerve injury regeneration and muscle activity.
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목차

  1. ABSTRACT
  2. Introduction
  3. Materials and Methods
  4. Results
  5. Discussion
  6. Acknowledgements
  7. References

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UCI(KEPA) : I410-ECN-0101-2013-528-002902436