인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 저자정보
피인용 0
초록·키워드
Capsaicin, the pungent alkaloid of red pepper has been studied extensively for its anti-inflammatory and anti-oxidant properties. Several studies have shown significant chemopreventive effects of capsaicin against several mutagens and carcinogens. Recent studies indicated that capsaicin suppresses cancer growth by inhibiting cell proliferation and induces apoptosis. Although, capsaicin is a TRPV1 agonist, various reports indicated that the anti-cancer effect of capsaicin is independent of TRPV1. Our studies have shown that capsaicin suppresses the growth of various pancreatic cancer cells and induces apoptotic death. Interestingly, effects of capsaicin were more specific to cancer cells with little or no toxicity towards normal human pancreatic cells. By modulating mitochondrial electron transport complexes, capsaicin generates reactive oxygen species and disrupts mitochondrial functions of pancreatic cancer cells, resulting in the release of cytochrome c into the cytosol and activating caspase-3 cascade. In addition, capsaicin reduces the levels of cellular antioxidants like glutathione, thioredoxin and superoxide dismutase. Capsaicin also inhibits beta catenin pathway and acetylates FOXO-1 through CBP, leading to apoptosis. Oral administration of 5mg/kg capsaicin suppresses the growth of various pancreatic tumor cells in xenograft and orthotopic tumor model. In addition, 10 p.p.m. capsaicin in diet for eight weeks significantly suppresses chronic pancreatitis and progression of PanIN-1 to high grade PanIN-2 and PanIN-3 lesions in KRas<SUP>G12D</SUP>/Pdx-1 mouse model of pancreatic cancer. When given in combination, capsaicin significantly potentiates the anti-tumor effects of gemcitabine. In conclusion, capsaicin targets multiple survival pathways in pancreatic cancer cells resulting in overall tumor growth suppression. [Supported by R01 grant CA129038 awarded by the National Cancer Institute. NIH]
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
최근 본 자료 전체보기
UCI(KEPA) : I410-ECN-0101-2016-519-002373785
