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논문 기본 정보

자료유형
학술저널
저자정보
(Seoul National University College of Medicine) (Seoul National University College of Medicine) (Seoul National University College of Medicine)
저널정보
대한면역학회 Immune Network Immune Network Vol.17 No.1
발행연도
수록면
60 - 67 (8page)

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초록· 키워드

Chronic rhinosinusitis (CRS) is one of the most common presentations of upper airway illness and severely affects patient quality of life. Its frequency is not surprising given levels of environmental exposure to microbes, pollutants, and allergens. Inflammatory cells, inflammatory cytokine and chemokine production, and airway remodeling have been detected in the sinonasal mucosae of CRS patients, although the precise pathophysiological mechanisms causing such persistent inflammation remain unclear. Given its high prevalence and considerable associated morbidity, continued research into CRS is necessary to increase our understanding of factors likely to contribute to its pathogenesis, and facilitate the development of novel therapeutic strategies to improve treatment. The purpose of this review is to summarize the current state of knowledge regarding immune cell responses and epithelial alterations in CRS.
#Chronic rhinosinusitis #Nasal polyps #Nasal mucosa #Cytokines #Eosinophils #Epithelial-mesenchymal transition
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  1. INTRODUCTION
  2. Varied immune cell responses in CRS : Western vs. Asian patients
  3. The nasal epithelium in CRS –much more than a passive barrier
  4. Conclusions
  5. REFERENCES

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