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자료유형
학술저널
저자정보
(Daegu Technical University) (Gyongbuk Science College) (Keimyung University)
저널정보
계명대학교 자연과학연구소 Quantitative Bio-Science Quantitative Bio-Science Vol.37 No.1
발행연도
수록면
49 - 55 (7page)

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초록· 키워드

A variety of commercially processed ginseng products, including black snow ginseng (BSG), sun ginseng (SG), and red ginseng (RG) are currently available in the market. To evaluate the anti-wrinkle effects of Panax ginseng (BSG, SG, and RG) water extracts (PGWEs: BSGWE, SGWE, and RGWE), collagen synthesis and degradation abilities of PGWEs were assessed using human dermal fibroblasts. BSGWE, SGWE, and RGWE at the concentration of 50 ㎍/mL increased type-I procollagen synthesis by 82.7% (p＜0.001), 26.9% (p＜0.01), and 119.2% (p＜0.001), respectively, in comparison to control cells. In comparison to control cells, treatments with 50 ㎍/mL of BSGWE, SGWE, and RGWE significantly (p＜0.001) decreased the activity of matrix metalloproteinase-2 (MMP-2) and the mRNA and protein expression of MMP-1. PGWEs were found to promote collagen synthesis and inhibit its degradation in human dermal fibroblasts. Among PGWEs, RGWE showed the most effective anti-wrinkle effects.
#Black snow ginseng #Collagen synthesis and degradation #MMP #Red ginseng #Sun ginseng
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목차

  1. Abstract
  2. Introduction
  3. Materials and Methods
  4. Results
  5. Discussion
  6. References

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UCI(KEPA) : I410-ECN-0101-2018-047-002155024