Low Serum Pancreatic Amylase and Lipase Values Are Simple and Useful Predictors to Diagnose Chronic Pancreatitis

오형철; 권창일; Ihab I. El Hajj; Jeffrey J. Easler; James Watkins; Evan L. Fogel; Lee McHenry; Stuart Sherman; Michelle K. Zimmerman; Glen A. Lehman

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저자정보: 오형철 권창일 Ihab I. El Hajj Jeffrey J. Easler James Watkins Evan L. Fogel Lee McHenry Stuart Sherman Michelle K. Zimmerman Glen A. Lehman

저널정보: 거트앤리버 발행위원회 Gut and Liver Gut and Liver 제11권 제6호

발행연도: 2017.1

수록면: 878 - 883 (6page)

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Background/Aims: This study aimed to evaluate the diagnostic role of low serum amylase and lipase values in the detection of chronic pancreatitis. Methods: Patients underwent endoscopic retrograde cholangiopancreatography and were diagnosed with non-calcific chronic pancreatitis (NCCP; n=99) and calcific chronic pancreatitis (CCP; n=112). Patient serum amylase and lipase values were compared with those of healthy controls (H; n=170). Results: The median serum amylase (normal range, 19 to 86 U/L) and lipase values (7 to 59 U/L) (P25–P75) were 47.0 (39.8 to 55.3) and 25.0 (18.0 to 35.0) for H, 34.0 (24.5 to 49.0) and 19.0 (9.0 to 30.0) for NCCP, and 30.0 (20.0 to 40.8) and 10.0 (3.0 to 19.0) for CCP, respectively. The cutoff values with the highest diagnostic accuracy for discriminating NCCP from H were 40 U/L for amylase and 20 U/L for lipase, respectively, and for CCP from H were 38 U/L for amylase and 15 U/L for lipase, respectively. For the diagnosis of NCCP with a criterion of serum amylase <40 and lipase <20 U/L, the sensitivity, specificity, positive predictive value, and negative predictive values were 37.4%, 88.8%, 66.1%, and 70.9%, respectively. Conclusions: Serum amylase and/or lipase levels below the normal serum range are highly specific for chronic pancreatitis patients. Clinicians should not ignore low serum pancreatic enzyme values.

#Amylases #Lipase #Pancreatitis #chronic

참고문헌 (13)

참고문헌 신청

Ammann RW / 1984 / Course and outcome of chronic pancreatitis: longitudinal study of a mixed medical-surgical series of 245 patients / Gastroenterology 86 (5 Pt 1) : 820 ~ 82

Ammann RW / 1999 / The natural history of pain in alcoholic chronic pancreatitis / Gastroenterology 116 : 1132 ~ 1140

Andriulli A / 1981 / Circulating trypsin-like immunoreactivity in chronic pancreatitis / Dig Dis Sci 26 : 532 ~ 537

Benini L / 1991 / Variations in time of serum pancreatic enzyme levels in chronic pancreatitis and clinical course of the disease / Int J Pancreatol 8 : 279 ~ 287

Borgstrom A / 1984 / Correlation between serum concentrations of three specific exocrine pancreatic proteins and pancreatic duct morphology at ERCP examinations / Scand J Ga

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