지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 79 - 84 (6page)
이용수
초록· 키워드
오류제보하기
Background and Purpose Te neuroregenerative drug Cerebrolysin has demonstrated efcacy in improving cognition in adults with stroke and Alzheimer’s disease. Te aim of this study was to determine the efcacy and safety of Cerebrolysin in the treatment of communication defects in infants with severe perinatal brain insult.
Methods A randomized placebo-controlled clinical trial was conducted in which 158 infants (age 6–21 months) with communication defects due to severe perinatal brain insult were enrolled; 120 infants completed the study. The Cerebrolysin group (n=60) received twice-weekly Cerebrolysin injections of 0.1 mL/kg body weight for 5 weeks (total of ten injections). Te placebo group (n=60) received the same amount and number of normal saline injections.
Results Te baseline Communication and Symbolic-Behavior-Scale-Developmental Profle scores were comparable between the two groups. Afer 3 months, the placebo group exhibited improvements in the social (p<0.01) and speech composite (p=0.02) scores, with 10% and 1.5% increases from baseline, respectively. Te scores of the Cerebrolysin group changed from concern to no concern, with increases of 65.44%, 45.54%, 358.06%, and 96.00% from baseline in the social (p<0.001), speech (p<0.001), symbolic (p<0.001), and total (p<0.001) scores.
Conclusions Cerebrolysin dramatically improved infants’ communication especially symbolic behavior which positively afected social interaction. Tese fndings suggest that cerebrolysin may be an efective and feasible way equivalent to stem cell therapy.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Vannucci RC / 1997 / Interventions for perinatal hypoxic-ischemic encephalopathy / Pediatrics 100:1004~1014
Adamson SJ / 1995 / Predictors of neonatal encephalopathy in full-term infants / BMJ 311:598~602
Johnston MV / 2011 / Treatment advances in neonatal neuroprotection and neurointensive care / Lancet Neurol 10:372~382
El Shimi MS / 2014 / Single dose recombinant erythropoietin versus moderate hypothermia for neonatal hypoxic ischemic encephalopathy in low resource settings / J Matern Fetal Neonatal Med 27:1295~1300
Nordberg A / 2013 / Speech problems affect more than one in two children with cerebral palsy:Swedish population-based study / Acta Paediatr 102:161~166
Adamson SJ / 1995 / Predictors of neonatal encephalopathy in full-term infants / BMJ 311:598~602
Johnston MV / 2011 / Treatment advances in neonatal neuroprotection and neurointensive care / Lancet Neurol 10:372~382
El Shimi MS / 2014 / Single dose recombinant erythropoietin versus moderate hypothermia for neonatal hypoxic ischemic encephalopathy in low resource settings / J Matern Fetal Neonatal Med 27:1295~1300
Nordberg A / 2013 / Speech problems affect more than one in two children with cerebral palsy:Swedish population-based study / Acta Paediatr 102:161~166
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