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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objective : Mesangial cell proliferation and excessive accumulation of extracellular matrix (ECM) proteins is the common pathologic feature of glomerulosclerosis, and platelet-derived growth factor (PDGF) BB-chain, transforming growth factor beta1 (TGF-β1), cyclin dependent kinases (CDK) and CDK inhibitors mediated in these pathophysiological processes. Bupleurum falcatum which is one of the most widely used components in traditional oriental medicines, has multiple pharmacological effects, such as antipyretic, analgesic, immune modulating, anti-inflammatory, anti-allergic, anti-thrombotic, anti-atherosclerotic, and antitussive effects.
Methods : In this study, we evaluated the influence of Bupleurum falcatum on mesangial cell proliferation, DNA synthesis and expression of PDGF-BB chain, TGF-β1, CDK1, CDK2, CDK4, p21 and p27 in fetal bovine serum (FBS)-activated human mesangial cell.
Results : Bupleurum falcatum reduced the mesangial cell proliferation and DNA synthesis more than control and captopril. And in the ELISA analysis of TGF-β1, and RT-PCR of PDGF-BB chain, CDK1, CDK2, CDK4, p21, and p27, Bupleurum falcatum inhibited the expression of TGF-β1 protein and PDGF-BB, CDK1, CDK2 gene and promoted that of p21 gene in a dose-dependent manner in comparing with control and captopril.
Conclusions : These results suggest that Bupleurum falcatum may inhibit the mesangial cell proliferation and DNA synthesis by regulation of PDGF-BB and TGF-β1 expressions, and by modulation of CDK1, CDK2 and p21 expression.
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참고문헌 (20)
참고문헌 신청
/ / Changes in cell-cycle protein expression during experimental mesangial proliferative glomerulonephritis : 1230 ~ 9
/ 1986 / Effects of saikosaponin-d on aminonucleoside nephrosis in rats 120 : 171 ~ 8
/ 1990 / Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1 346 : 371 ~ 4
/ 1991 / Studies on antinephritic effects of plant components in rats Effects of saikosaponins original-type anti-GBM nephritis in rats and its mechanisms : 13 ~ 21
/ 1992 / Long-term beneficial effects of angiotensin-converting enzyme inhibition in patients with nephrotic proteinuria : 240 ~ 8
/ 1986 / Effects of saikosaponin-d on aminonucleoside nephrosis in rats 120 : 171 ~ 8
/ 1990 / Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1 346 : 371 ~ 4
/ 1991 / Studies on antinephritic effects of plant components in rats Effects of saikosaponins original-type anti-GBM nephritis in rats and its mechanisms : 13 ~ 21
/ 1992 / Long-term beneficial effects of angiotensin-converting enzyme inhibition in patients with nephrotic proteinuria : 240 ~ 8
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