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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 185 - 195 (11page)
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초록· 키워드
오류제보하기
Previous studies have demonstrated that rottlerin, a specific PKCδ inhibitor, potentiates death receptor- mediated apoptosis through a cytochrome c-depend-ent or -independent pathway. However, its ability to regulate necrotic cell death, as well as the underlying ine fibrosarcoma L929 cells, treatment with rotlerin protected the cells against TNF-induced necrosis, whereas it sensitized the cels to apoptosis induced by co-treatment with Hsp90 inhibitor geldanamycin and TNF, in a maner independent of its ability to inhibit PKC-δ. TNF treatment induced rapid accumulation of mitochondrial superoxide (O2-) through the Nox1 NADPH oxidase when cells undergo necrosis. More-GTP-bound form of small GTPase Rac1 by TNF treat-ment, and subsequently suppressed mitochondrial O2- production and poly(ADP-ribose) polymerase activa-tion, thus inhibiting necrotic cell death. Therefore, our study suggests that Nox1 NADPH oxidase is a new mo-lecular target for anti-necrotic activity of rotlerin upon death-receptor ligation.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Banfi B / 2003 / Two novel proteins activate superoxide generation by the NADPH oxidase NOX1 / J Biol Chem 278 : 3510 ~ 3
Byun HS / 2006 / Phorbol 12-myristate 13-acetate protects against tumor necrosis factor (TNF)-induced necrotic cell death by modulating the recruitment of TNF receptor 1-asso
Cheng G / 2006 / Nox1-dependent reactive oxygen generation is regulated by Rac1 / J Biol Chem 281 : 17718 ~ 26
Fas SC / 2006 / Death receptor signaling and its function in the immune system / Curr Dir Autoimmun 9 : 1 ~ 17
Fiers W / 1999 / More than one way to die: apoptosis, necrosis and reactive oxygen damage / Oncogene 18 : 7719 ~ 30
Byun HS / 2006 / Phorbol 12-myristate 13-acetate protects against tumor necrosis factor (TNF)-induced necrotic cell death by modulating the recruitment of TNF receptor 1-asso
Cheng G / 2006 / Nox1-dependent reactive oxygen generation is regulated by Rac1 / J Biol Chem 281 : 17718 ~ 26
Fas SC / 2006 / Death receptor signaling and its function in the immune system / Curr Dir Autoimmun 9 : 1 ~ 17
Fiers W / 1999 / More than one way to die: apoptosis, necrosis and reactive oxygen damage / Oncogene 18 : 7719 ~ 30
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